Research Advances on Natural Products in Maintaining Oral Microecological Balance
Abstract
The oral cavity is a complex microecosystem that provides a suitable habitat for diverse microorganisms, including bacteria, archaea, fungi, viruses, and protozoa. The microbial communities in the oral cavity form a stable microecology through complex interactions and environmental adaptation. In a healthy oral microenvironment, various microorganisms maintain microecological balance through signal communication, material exchange, competition and cooperation for resources and environmental conditions, quorum sensing, and environmental adaptation. In contrast, an imbalanced oral microecology can lead to oral diseases such as endodontic and periodontal diseases, and may even affect systemic health. Natural products have attracted significant attention for maintaining oral microecological balance due to their potential antibacterial, anti-inflammatory, biofilm-inhibiting, and microecology-regulating properties. This article systematically reviews the characteristics of natural products, their mechanisms for regulating oral microecological balance, and their application prospects and limitations in oral disease prevention and treatment, providing a reference for the use of natural products in maintaining oral microecological balance.
Keywords: Oral microecology, Natural products, Oral diseases, Antibacterial, Microecological balance, Review
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JENKINSON H F, LAMONT R J. Oral microbial communities in sickness and in health. Trends Microbiol, 2005, 13(12): 589-595. doi: 10.1016/j.tim. 2005.09.006.
HAJISHENGALLIS G, LAMONT R J, KOO H. Oral polymicrobial communities: assembly, function, and impact on diseases. Cell Host Microbe, 2023, 31(4): 528-538. doi: 10.1016/j.chom.2023.02.009.
PENG X, CHENG L, YOU Y, et al. Oral microbiota in human systematic diseases. Int J Oral Sci, 2022, 14(1): 14. doi: 10.1038/s41368-022-00163-7.
CAO X, CHENG X W, LIU Y Y, et al. Inhibition of pathogenic microbes in oral infectious diseases by natural products: Sources, mechanisms, and challenges. Microbiol Res, 2024, 279: 127548. doi: 10.1016/j.micres.2023. 127548.
KULIS E, CVITKOVIC I, PAVLOVIC N, et al. A comprehensive review of antibiotic resistance in the oral microbiota: mechanisms, drivers, and emerging therapeutic strategies. Antibiotics, 2025, 14(8): 828. doi: 10. 3390/antibiotics14080828.
CHI Y, WANG Y, JI M, et al. Natural products from traditional medicine as promising agents targeting at different stages of oral biofilm development. Front Microbiol, 2022, 13: 955459. doi: 10.3389/fmicb.2022. 955459.
LI Z Y, ZHOU X D, PENG X. Regulation of oral microbiota homeostasis and oral diseases. Chin J Stomatol, 2024, 59(2): 124-129. doi: 10.3760/cma.j.cn112144-20231012-00189.
MARSH P D. In sickness and in health—what does the oral microbiome mean to us? An ecological perspective. Adv Dent Res, 2018, 29(1): 60-65. doi: 10.1177/0022034517735295.
TAKAHASHI N, NYVAD B. The role of bacteria in the caries process: ecological perspectives. J Dent Res, 2011, 90(3): 294-303. doi: 10.1177/ 0022034510379602.
RAJASEKARAN J J, KRISHNAMURTHY H K, BOSCO J, et al. Oral microbiome: a review of its impact on oral and systemic health. Microorganisms, 2024, 12(9): 1797. doi: 10.3390/microorganisms 12091797.
BENNY B, PILLAI V R, JOSEPH A, et al. Oral microbes associated with pulp and periapical infections. J Orofacial Sci, 2022, 14(1): 52-61. doi: 10. 4103/jofs.jofs_268_21.
ALSAHAFI R, MITWALLI H, ALHUSSEIN A, et al. Novel rechargeable nanostructured calcium phosphate crown cement with long-term ion release and antibacterial activity to suppress saliva microcosm biofilms. J Dent, 2022, 122: 104140. doi: 10.1016/j.jdent.2022.104140.
GOMES B P, PINHEIRO E T, GADÊ-NETO C R, et al. Microbiological examination of infected dental root canals. Oral Microbiol Immunol, 2004, 19(2): 71-76. doi: 10.1046/j.0902-0055.2003.00116.x.
JAKUBOVICS N S, GOODMAN S D, MASHBURN-WARREN L, et al. The dental plaque biofilm matrix. Periodontol 2000, 2021, 86(1): 32-56. doi: 10.1111/prd.12361.
TAMAI R, DENG X, KIYOURA Y. Porphyromonas gingivalis with either Tannerella forsythia or Treponema denticola induces synergistic IL-6 production by murine macrophage-like J774.1 cells. Anaerobe, 2009, 15(3): 87-90. doi: 10.1016/j.anaerobe.2008.12.004.
ZHANG M, LI R, ZHOU Y, et al. The promotional effect of GW4869 on C. albicans invasion and cellular damage in a murine model of oral candidiasis . Pathogens, 2022, 11(12): 1522. doi: 10.3390/pathogens11121522.
MOHAMMED L I, ZAKARIA Z Z, BENSLIMANE F M, et al. Exploring the role of oral microbiome dysbiosis in cardiometabolic syndrome and smoking.Exp Lung Res, 2024, 50(1): 65-84. doi: 10.1080/01902148.2024. 2331185.
RODRIGUES C F, RODRIGUES M E, HENRIQUES M C R. Promising alternative therapeutics for oral candidiasis. Curr Med Chem, 2019, 26(14): 2515-2528. doi: 10.2174/0929867325666180601102333.
SURLARI Z, CIURCANU O E, BUDALA D G, et al. An update on the interdisciplinary dental care approach for geriatric diabetic patients. Geriatrics, 2023, 8(6): 114. doi: 10.3390/geriatrics8060114.
NAPEñAS J J, BRENNAN M T, COLEMAN S, et al. Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010, 109(4): 554-560. doi: 10.1016/j.tripleo.2009.11.015.
STEHLIKOVA Z, TLASKAL V, GALANOVA N, et al. Oral microbiota composition and antimicrobial antibody response in patients with recurrent aphthous stomatitis. Microorganisms, 2019, 7(12): 636. doi: 10. 3390/microorganisms7120636.
BELIBASAKIS G N, SENEVIRATNE C J, JAYASINGHE R D, et al. Bacteriome and mycobiome dysbiosis in oral mucosal dysplasia and oral cancer. Periodontology 2000, 2024, 96(1): 95-111. doi: 10.1111/prd.12558.
GOSWAMI G R, PATIL R, GHOSH S, et al. Oral microbiome modulates tumor micro-environment potentiating oral cancer progression from benign stages- a review. Current Dentistry, 2025, 4(1): 14. doi: 10.2174/ 012542579X323179250224063708.
BAIMA G, MINOLI M, MICHAUD D S, et al. Periodontitis and risk of cancer: mechanistic evidence. Periodontol 2000, 2024, 96(1): 83-94. doi: 10.1111/prd.12540.
BI R, YANG Y, LIAO H, et al. Porphyromonas gingivalis induces an inflammatory response via the cGAS-STING signaling pathway in a periodontitis mouse model. Front Microbiol, 2023, 14: 1183415. doi: 10. 3389/fmicb.2023.1183415.
SUN J, TANG Q, YU S, et al. F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. EBioMedicine, 2023, 88: 104444. doi: 10.1016/j.ebiom.2023.104444.
DIWAN P, NIRWAN M, BAHUGUNA M, et al. Evaluating alterations of the oral microbiome and its link to oral cancer among betel quid chewers: prospecting reversal through probiotic intervention. Pathogens, 2023, 12(8): 996. doi: 10.3390/pathogens12080996.
SAIKIA P J, PATHAK L, MITRA S, et al. The emerging role of oral microbiota in oral cancer initiation, progression and stemness. Front Immunol, 2023, 14: 1198269. doi: 10.3389/fimmu.2023.1198269.
MEIER R, THOMPSON J A, CHUNG M, et al. A Bayesian framework for identifying consistent patterns of microbial abundance between body sites. Stat Appl Genet Mol Biol, 2019, 18(6): 20190027. doi: 10.1515/sagmb-2019-0027.
MAGER L F, KRAUSE T, MCCOY K D. Interaction of microbiota, mucosal malignancies, and immunotherapy—mechanistic insights. Muco Immunol, 2024, 17(3): 402-415. doi: 10.1016/j.mucimm.2024.03.007.
JOHNSTON C D, BULLMAN S. The tumour-associated microbiome. Nat Rev Gastroenterol Hepatol, 2022, 19(6): 347-348. doi: 10.1038/s41575-022-00609-7.
ATANASOV A G, ZOTCHEV S B, DIRSCH V M, et al. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov, 2021, 20(3): 200-216. doi: 10.1038/s41573-020-00114-z.
BOUFRIDI A, QUINN R J. Harnessing the properties of natural products. Annu Rev Pharmacol Toxicol, 2018, 58(1): 451-470. doi: 10.1146/annurev-pharmtox-010716-105029.
De ALMEIDA J D, NASCIMENTO M F, KEKOVIĆ P, et al. Unlocking the potential of mannosylerythritol lipids: properties and industrial applications. Fermentation, 2024, 10(5): 246. doi: 10.3390/fermentation10050246.
PHAM J V, YILMA M A, FELIZ A, et al. A review of the microbial production of bioactive natural products and biologics. Front Microbiol, 2019, 10: 1404. doi: 10.3389/fmicb.2019.01404.
HU S, WANG B, PEI L, et al. Advances and challenges in biomanufacturing of glycosylation of natural products. Fermentation, 2024, 10(7): 349. doi: 10.3390/fermentation10070349.
PFEIFFER I P M, SCHRÖDER M P, MORDHORST S. Opportunities and challenges of RiPP-based therapeutics. Nat Prod Rep, 2024, 41(7): 990-1019. doi: 10.1039/D3NP00057E.
HONG J. Role of natural product diversity in chemical biology. Curr Opin Chem Biol, 2011, 15(3): 350-354. doi: 10.1016/j.cbpa.2011.03.004.
WALKER K L, LOACH R P, MOVASSAGHI M. Total synthesis of complex 2, 5-diketopiperazine alkaloids. Alkaloids Chem Biol, 2023, 90: 159-206. doi: 10.1016/bs.alkal.2023.06.002.
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