A Randomized Controlled Clinical Trial of Acupuncture at the Sphenopalatine Ganglion for the Treatment of Allergic Rhinitis
Abstract
Objective
To evaluate the clinical efficacy and safety of acupuncture at the sphenopalatine ganglion (SPG) for the treatment of allergic rhinitis (AR).
Methods
A randomized controlled trial design was used. A total of 120 patients with AR were randomly assigned in a 1∶1 ratio to either the experimental group (acupuncture on the SPG, twice a week for 2 weeks) or the control group (oral lupatadine fumarate tablets, 10 mg daily for 2 weeks). The primary outcome measures were nasal symptom and sign scores at 1 and 2 weeks after treatment. Secondary outcome measures included the total non-nasal symptom score (TNNSS) and the rhinoconjunctivitis quality of life questionnaire (RQLQ) score.
Results
Four cases were excluded from both the experimental group and the control group. Ultimately, 56 cases in each group completed the study. After two weeks of treatment, the total effective rates were 82.1% for the experimental group and 87.5% for the control group, with no statistically significant difference. At each time point after treatment, the symptom scores, sign scores, TNNSS, and RQLQ scores in both groups decreased compared to baseline, and these differences were statistically significant (P < 0.001). Generalized estimating equation (GEE) analysis showed that the improvement trends for most indicators were consistent between the two groups, but there was a "group × time" interaction, indicating that improvement in nasal congestion symptoms in the experimental group was greater than in the control group during the first week of treatment (experimental group: 2.0 [1.0, 2.0] vs. control group: 2.0 [1.0, 2.0], interaction P = 0.023). Forest plot analysis further showed that the standardized mean difference (SMD) for nasal congestion symptoms at one week of treatment was －0.420 (95% confidence interval: －0.795, －0.046), and the 95% confidence intervals for all indicators' SMD at two weeks crossed zero. Regarding safety, there was no statistically significant difference in the incidence of adverse events between the experimental and control groups.
Conclusion
Acupuncture on the SPG and oral administration of lupatadine fumarate can both effectively alleviate symptoms and improve the quality of life for patients with AR. The overall short-term efficacy is comparable. However, acupuncture on the SPG is more effective in relieving nasal congestion and has a good safety profile.
Keywords: Acupuncture, Sphenopalatine ganglion, Allergic rhinitis. Randomized controlled trial
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KABADAYI G, TRISCHLER J, HUTTER M, et a. Alternaria Sensitization and Allergy in Children and Adolescents: A Retrospective Diagnostic Study. J Asthma Allergy, 2025, 18: 1893-1902. doi: 10.2147/JAA.S562277. LIU S, ZHANG Y, LV J, et al. Traditional Chinese Medicine for Allergic Rhinitis: Mechanisms, Evidence, and Gut-Immune Axis Targets. J Asthma Allergy, 2026, 19: 1-23. doi: 10.2147/JAA.S571460.
JACOB J, JOYCE C, LLOYD M, et al. Patient perspectives of allergic rhinitis and allergen immunotherapy: A qualitative study. J Allergy Clin Immunol Glob, 2025, 5(2): 100621. doi: 10.1016/j.jacig.2025.100621.
DENG X Y, WANG G R, ZHANG T, et al. Meta-analysis of the prevalence of allergic rhinitis in individuals under 18 years old in China. Nursing Practice and Research, 2023, 20(10): 1550-1557. doi:10.3969/j.issn.1672-9676.2023.10.025.
SRIDMAN M D, GURGEL R K, LIN S Y, et al.Clinical practice guideline: Allergic rhinitis . Otolaryngol Head Neck Surg, 2015, 152(1): 1-43. doi: 10. 1177/0194599814561600.
ZHANG Y L, SUN W X, PENG Y R, et al. Clinical efficacy of intranasal acupuncture in the treatment of allergic rhinitis: a meta-analysis. Acupuncture Research, 2025, 50(12): 1482-1494. doi: 10.13702/j.1000-0607.20241322.
GENG Z, WANG C, WANG R, et al. Ultrasound guided pulsed radiofrequency neuromodulation of sphenopalatine ganglion treatment for allergic rhinitis in childern: A case report. Clin Case Rep, 2024, 12(9): e9436. doi: 10.1002/ccr3.9436.
Nasology Group of Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Nasology Group of Chinese Society of Otorhinolaryngology Head and Neck Surgery. Interpretation of Chinese guideline for diagnosis and treatment of allergic rhinitis(2022, revision). Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2022, 57(2): 106-129. doi: 10.3760/cma.j.cn115330
ZHU R F, LIU G H, LIANG J P, et al. A multicenter clinical trial to evaluate the efficacy and safety of rupatadine tablet in the treatment of allergic rhinitis. Chinese Journal of Hospital Pharmacy, 2010, 30(7): 584-587.
ZHANG P, YANG W, WANG K J, et al. A multi-center prospective case series study on the treatment of allergic rhinitis by acupuncture of sphenopalatine ganglion. Journal of Capital Medical University, 2019, 40(6): 916-920. doi: 10.3969/j.issn.1006-7795.2019.06.019.
PFAAR O, DEMOLY P, WIJK R G V, et al. Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper. Allergy, 2014, 69(7): 854-867. doi: 10.1111/all.12383.
JUNIPER E F, GUYATT G H, GRIFFITH L E, et al. Interpretation of rhinoconjunctivitis quality of life questionnaire data. J Allergy Clin Immunol, 1996, 98(4): 843-845.
ZHENG X Y. Guiding Principles for Clinical Research of New Traditional Chinese Drugs (Trial Implementation). Beijing: China Medical Science Press, 2002: 1-9.
BANJAR S A, ASSIRI R A, ALSHEHRI G A, et al. The impact of allergic rhinitis on asthma and its effect on the quality of life of asthmatic patients. Cureus, 2023, 15(3): e35714. doi: 10.7759/cureus.35714.
ZHANG P, QIN R, ZHANG W, et al. Distinct treatment response trajectories to allergen immunotherapy in allergic asthma and rhinitis: Insights from a multicenter study in routine clinical practice. World Allergy Organ J, 2026, 19(1): 101168. doi: 10.1016/j.waojou.2025.101168.
LUO W Q, HUANG Z Q, YE J. Research progress of allergen immunotherapy in allergic rhinitis. Chinese Journal of Preventive Medicine, 2025, 59(12): 2021-2033. doi: 10.3760/cma.j.cn112150-20250715-00676.
QIAO Y L, XU S, ZOU Y, et al. Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis. Adv Sci (Weinh), 2026: e11612. doi: 10.1002/advs.202511612.
DU L, CHENG X, LIU B, et al. A New Perspective on Nasal Microbiota Dysbiosis-Mediated Allergic Rhinitis: From the Mechanism of Immune Microenvironment Remodeling to Microbiota-Targeted Therapeutic Strategies. Int J Mol Sci, 2025, 26(24): 12061. doi: 10.3390/ijms262412061.
FANG D, ZHANG Y, ZHANG L. The latest investigational drugs for patients with allergic rhinitis. Expert Opin Investig Drugs, 2026, 35(1): 49-62. doi: 10.1080/13543784.2025.2612328.
MARTINS L, SILVESTRE S, MONTEIRO C. Risks associated with the use of intranasal corticosteroids: An analysis of adverse reactions reported to EudraVigilance. Healthcare (Basel), 2024, 12(19): 1923. doi: 10.3390/healthcare12191923.
RAMASAMY K, GENDEH H S, WAN HAMIZAN A K, et al. Histological Impact of Rhinophototherapy Compared to Intranasal Corticosteroids on Inflammatory Cells and Nasal Mucosa in Allergic Rhinitis. Ann Otol Rhinol Laryngol, 2026: 34894251401132. doi: 10.1177/00034894251401132.
PSHENNIKOV D S, FESHKINA N V, RONDALEVA A V. Possibilities of combined physiotherapy treatment of allergic rhinitis. Vestn Otorinolaringol, 2025, 90(6): 72-76. doi: 10.17116/otorino20259006172.
MOON J, SONG J, KIM J, et al. Management of Perennial Allergic Rhinitis Complicated by Rhinosinusitis Using Ultrasound-Guided Sphenopalatine Ganglion Acupuncture and Modified Socheongryong-
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