Insertion/Deletion Polymorphism of IL1A 3′-UTR Associated with the Susceptibility of Prostate Cancer

LIAO Hong, ZHANG Lin, CHENG Peng. et al

Abstract

To identify the association between the insertion/deletion polymorphism of interleukin-1A gene (IL1A) and the susceptibility of prostate cancer (PCA). Methods We performed a case-control study enrolling 131 PCA patients and 229 healthy control subjects in a Chinese Han population. The TTCA insertion/deletion polymorphism (rs3783553) in 3′-UTR of IL1A gene was genotyped by PCR-RFLP method. Results The genotype distribution of rs3783553 in both groups met the requirements of Hardy-Weinberg equilibrium. Significantly reduced PCA risk was associated with D/I and I/I genotype compared to D/D genotype (POR=0.48, 95%CI: 0.31-0.74), and allele I is associated with the reduced PCA risk (P=0.001，OR=0.56，95%CI: 0.40-0.79). Conclusion TTCA insertion allele of rs3783553 contributes to the reduction of the susceptibility to prostate cancer.

 

Keywords: Prostate cancer IL1A, Polymorphism, Susceptibility 

 

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References


Siegel R. Naishadham D, Jemal A. Cancer statistics,2013. CA Cancer J Clin,2013;63(l) : 11-30.

Hawkes N. Genetic tests could detect high risk of aggressive prostate cancer. BMJ, 2014; 348; gl700. doi; 10. 1136/bmj. gl700.

Gao Y, He Y, Ding J, et al. An insertion/deletion polymorphism at miRNA- 122-binding site in the interleukin- 1 alpha 3r untranslated region confers risk for hepatocellular carcinoma. Carcinogenesis,2009;30(12);2064-2069.

Yang ZH, Dai Q. Zhong L, et al. Association of IL-1 polymorphisms and IL-1 serum levels with susceptibility to nasopharyngeal carcinoma. Mol Carcinog, 2011; 50 ( 3 ): 208- 214.

Lu D, Chen L, Shi X. et al. A functional polymorphism in interleukin-lalpha (ILIA) gene is associated with risk of alopecia areata in Chinese populations. Gene. 2013 ; 521 ( 2 ): 282-286.

Chen P. Zhang K, Zhou B, et al. The variations in the IIARIA gene and susceptibility to preeclampsia. Immunol Invest,2014 ;43С5) :424-435.

Hata Y, Nakaoka H, Yoshihara K, et al. A nonsynonymous variant of ILIA is associated with endometriosis in Japanese population. J Hum Genet,2013;58(8) ;517-520.

Chen P. Zhou B, Zhang K. et al. An insertion-deletion polymorphism in interleukin-lalpha gene associated with susceptibility to preeclampsia. Hypertens Pregnancy ,2014 May 19; 1-7. [Epub ahead of print].

Pu Y, Zhang Z, Zhou B, et al. Association of an insertion/ deletion polymorphism in ILIA З'-UTR with risk for cervical carcinoma in Chinese Han Women. Hum Immunol, 2014; 75 (8):740-744.

Sole X, Guino E, Vails J, elal. SNPStats: a web tool for the analysis of association studies. Bioinformatics, 2006; 22 ( 15): 1928-1929.

Dupont WD. Plummer WD Jr. Power and sample size calculations. A review and computer program. Control Clin Trials,1990; 11(2) : 116-128.

Ma L, Zhao J, Li T, elal. Association between tumor necrosis factor-alpha gene polymorphisms and prostate cancer risk: a meta-analysis. Diagn Patho, 2014; 9: 74. doi; 10. 1186/1746- 1596-9-74.

Chin LJ, Ratner E, Leng S, et al. A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res,2008;68 (20);8535-8540.

Landi Г), Gemignani F. Naccarati A, et al. Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer. Carcinogenesis,2008;29(3);579-584.


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