Infiltrated T Cells Induce the Accumulation of Myeloid-derived Suppressor Cells in Tumor Microenvironment

LIU Xiao-yun, LIU Yan-tong, MAO Ye. et al

Abstract

To determine the role of infiltrated T cells in the accumulation of myeloid-derived suppressor cells ( MDSCs) in tumor microenvironment. Methods T-cell-deficient nude mice models were established using BALB/c mice. Growth of tumors was compared between those with and without adoptive transfer of T cells. Pathological changes of the tumors were examined with HE histological analysis. The levels of MDSCs were detected with flow cytometry (FACS). Results Tumor growth was promoted in T-cell-deficient nude mice, which was accompanied with lower levels of MDSCs compared with BALB/c mice (P<0. 05). T cell transfer increased the level of MDSCs significantly (P<0. 05). T cells depletion decreased the level of MDSCs (/J<0. 05). Conclusion Infiltrated T cells induce the accumulation of MDSCs in tumor microenvironment, and influence tumor growth.


Keywords: Tumor microenvironment Infiltrated T cells Myeloid-derived suppressor cells

 

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