Exploration of Renal Microcirculation Perfusion During Cardiopulmonary Bypass with Contrast-enhanced Ultrasound

ZHANG Lu, ZHANG Jing-yi, ZHONG Xiao-fei. et al

Abstract

To investigate the alteration of renal microcirculation perfusion during cardiopulmonary bypass (СРВ) in adult patients with contrast-enhanced ultrasound (CEU). Methods Six patients undergoing cardiac surgery with СРВ and twelve patients undergoing non-cardiac surgery were enrolled and classified into СРВ group and control group. CEU images of kidney were collected at the point of 30 min after СРВ or 5 min after anesthesia induction respectively. Time intensity curve (TIC) was derived from three regions of interest (R()I): superficial cortex, deep cortex and medulla. Parameters including wash in slope (a), area under curve (AUC), peak intensity (PI) and time to peak (TTP) were calculated based on gamma-variant function. Results CEU showed a significant reduction of AUC in all three regions (superficial cortex, deep cortex and medulla) during СРВ» compared with anesthetic condition. Ultrasound contrast agent-related adverse reactions were not occurred in all enrolled patients. Conclusion Renal microcirculation perfusion was dramatically reduced during СРВ, especially in the medulla. CEU could be detected the renal microcirculation perfusion in the perioperative period of cardiac surgery.

 

Keywords: Contrast-enhanced ultrasound,  Cardiopulmonary bypass, Renal microcirculation perfusion


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