Expression Difference of MicroRNAs in Colorectal Adenoma and Colorectal Cancer

ZHU Lin-lin, CHEN Wei, WANG Jin. et al

Abstract

To investigate the expression difference of microRNAs in colorectal tubular adenoma, tubulovillous adenoma and colorectal cancer. Methods Real time-polymerase chain reaction was used to analysis the expression level of miR-1, miR-9, miR-31, miR-135a, miR-137 and miR-145 between colorectal tubular adenoma (;? = 44),tubulovillous adenoma ( n = 16 ) , colorectal cancer (;/ = 20 ) and paired paracancerous normal colorectal tissues. Results Compared with paired paracancerous normal colorectal tissues, colorectal tubular adenoma had decreased expression of miR-1, miR-9, miR-137 and miR-145 as well as increased expression of miR-31 and miR- 135a. Colorectal tubulovillous adenoma had decreased levels of miR-1, miR-137, miR-145, as well as increased levels of miR-9, miR-135a, and miR-31. Colorectal cancer had the expressions of miR-1, miR-9, miR-137 and miR- 145 decreased while the expression of miR-135a and miR-31 increased. Conclusion The differential expressions of microRNAs suggested that miRNAs participate in the development of colorectal adenoma and cancer.


Keywords: Colorectal adenoma, Colorectal cancer, MicroRNA

 

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References


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