The Effect of Emulsified Sevofluran on Muscular Relaxation through Selective Blockage of Peripheral Nerves
Abstract
To identify the site that emulsified sevoflurane influences in the nerve system. Methods Thirty-six healthy New Zealand rabbits were randomly and equally divided into low concentration emulsified sevoflurane group 〔4 mL/（kg·h）〕, medium concentration 〔6 mL/（kg·h）〕group, high concentration group〔10 mL/（kg·h）〕and intralipid control group. Emulsified sevoflurane was infused through arterial to selectively block peripheral nerves, neuro-muscular junctions and muscle fibers. The anterior tibial muscle resting tensions and muscle contraction forces were compared before and after the infusions. Results Significant differences of blood sevoflurane pressure between femoral veins and internal jugular veins appeared in rabbits in all the groups ( P<0.05). No significant changes in the resting tension of anterior tibia muscles were found in terms of single contractions and tetanic forces with the low and medium levels of infusion of sevoflurane compared to the base values. High level of infusion of sevoflurane resulted in decreased single contraction forces and tetanic forces of anterior tibia muscles ( P<0.05). Conclusion A rabbit model with selective blockage of peripheral nerves was established. Peripheral nerves are not the primary site which low and medium levels of emulsified sevoflurane influence skeletal muscle relaxations.
Keywords: Emulsified sevofluran, Selective anesthetics delivery models, Muscle relaxation
Full Text:
PDFReferences
KIHARA S, YAGUCHI Y. I NOMAT A S. et al. Influence of nitrous oxide on minimum alveolar concentration of sevoflurane for laryngeal mask insertion in children. Anesthesiology, 2003,99(5):1055-1058.
КАТОН T, NAKAJIMA Y, MORIWAKI G, et al. Sevoflurane requirements for tracheal intubation with and without fentanyl. Br J Anaesth, 1999,82(4);561 -565. CAMPAGNAJA, MILLER KW, FORMAN SA. Mechanisms of actions of inhaled anesthetics. N Engl J Med, 2003,348(21);2110-2124.
YANG J, CHAI YF, GONG CY, et al. Further proof that the spinal cord, and not the brain, mediates the immobility produced by inhaled anesthetics. Anesthesiology, 2009, 110 (3):591-595.
CHAI YF, YANGJ, LIUJ, et al. Epidural anaesthetic effect of the 8% emulsified isoflurane; a study in rabbits. Br J Anaesth,2008,100( 1): 109-115.
BIEDA MC, SU H, MACIVER MB. Anesthetics discriminate between tonic and phasic gamma-aminobutyric acid receptors on hippocampal CA1 neurons. Anesth Analg, 2009, 108 (2 ) ; 484-490.
CAMMU G, DE WITTE J, DE VEYLDER J, et al. Posto¬perative residual paralysis in outpatients versus inpatients. Anesth Analg.2006,102(2) :426-429.
WRIGHT PM, HART P, LAU M.et al. The magnitude and time course of vecuronium potentitation by desflurane versus isoflurane. Anesthesiology, 1995 ,82(2):404-411.
MURPHY GS, SZOKOL JW, MARYMONT JH. et al. Intraoperative acceleromyographic monitoring reduces the risk of residual neuromuscular blockade and adverse respiratory events in the postanesthesia care unit. Anesthesiology. 2008,109(3): 389-398.
MURPHY GS, SZOKOL JW, MARYMONT JH. et al. Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit. Anesth Analg,2008. 107(1):130-137.
El К ER MANN M. GROEBEN H. HUSING J. et al. Accelerometry of adductor pollicis muscle predicts recovery of respiratory function from neuromuscular blockade. Anesthesiology.2003.98(6): 1333-1337.
SUNDMAN E, WITT H, OLSSON R, et al. The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans. Pharyngeal videoradiography and simultaneous manometry after atracurium. Anesthesiology,2000,92(4) :977-984.
ERIKSSON LI. SUNDMAN E. OLSSON R. et al. Functional assessment of the pharynx at rest and during swallowing in partially paralyzed humans; simultaneous videomanometry and mechanomyography of awake human volunteers. Anesthesiology, 1997.87(5); 1035-1043.
PITTION-VOUYOVITCH S, DEBOUVERIE M, GUILLEMIN F. et al. Fatigue in multiple sclerosis is related to disability, depression and quality of life. J Neurol Sci, 2006.243(1/2): 39-45.
HE D, CHEN X. ZHAO D, et al. Cognitive function, depression, fatigue, and activities of daily living in patients with neuromyelitis optica after acute relapse. Int J Neurosci, 2011.121(12):677-683.
WINGERCHUK DM, LENNON VA, PITTOCK SJ, et al. Revised diagnostic criteria for neuromyelitis optica. Neurology,2006,66( 10): 1485-1489.
FISK JD, RITVO PG, ROSS L. et al. Measuring the functional impact of fatigue; initial validation of the fatigue impact scale. Clin Infect Dis, 1994 ,18(Suppl 1);S79-S83.
CHANSON JB, ZEPHIR H, COI-LONGUES N, et al. Evaluation of health-related quality of life, fatigue and depression in neuromyelitis optica. Eur J Neurol, 2011, 18 (6):836-841.
PANJ. ZHAO P. CAI H, et al. Hypoxemia, Sleep Disturbances, and Depression Correlated with Fatigue in Neuromyelitis Optica Spectrum Disorder. CNS Neurosci Ther,2015,21(7) :599-606.
HUH SY, KIM SH, HYUN JW, et al. Mycophenolate mofetil in the treatment of neuromyelitis optica spectrum disorder. JAMA Neurol.2014 ,71( 11); 1372-1378.
QIU W, KERMODE AC, LI R, et al. Azathioprine plus corticosteroid treatment in Chinese patients with neuromyelitis optica. J Clin Neurosci, 2015, 22 ( 7): 1178- 1182.
KAGEYAMAT, KOMORI M, MIYAMOTO K, et al. Combination of cyclosporine A with corticosteroids is effective for the treatment of neuromyelitis optica. J Neurol,2013,260 (2):627-634.
ARAKI M, MATSUOKA T, MIYAMOTO K. et al. Efficacy of the anti-IL-6 receptor antibody tocilizumab in neuromyelitis optica; a pilot study. Neurology,2014 ,82(15): 1302-1306.
Refbacks
- There are currently no refbacks.
