The Early Diagnosis of Lung Cancer The Methods and Clinical Significance of Early Diagnosis of Lung Cancer
Abstract
Lung cancer is the leading contributor to morbidity and mortality from cancer worldwide, with its 5-year overall survival being only about 15.6%. Due to the lack of specific early screening methods for lung cancer, about 75% patients are diagnosed late. Therefore, it remains the big challenge for the early diagnosis of lung cancer. We need to pay more attention to the screening of lung cancer, and more precise assessment and management to the pulmonary nodules screened out. Further study on liquid biopsy, optimization of new fiberoptic bronchoscopy and the sampling methods to harvest small volume of lung tissue, could be helpful to improve the early diagnosis of lung cancer.
Keywords: Lung cancer, Early diagnosis
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WOODARD GA, JONES KD. JABLONS DM. Lung Cancer Staging and Prognosis. Cancer Treat Res, 2016, 170: 47-75. doi: 10. 1007/978-3-319-4 0389-2_3.
National Lung Screening Trial Research Team, ABERLE DR. ADAMS AM. et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med, 2011,365(5);395-409.
SMITH RA, BROOKS D. COKKINIDES V, et al. Cancer screening in the United States, 2013. A review of current American Cancer Society guidelines, current issues in cancer screening.and new guidance on cervical cancer screening and lung cancer screening. CA Cancer J Clin, 2013, 63 ( 1 ) : 87- 105.
CHEN X. ZHOU F. LI X, et al. Folate Receptor-Positive Circulating Tumor Cell Detected by LT-PCR-Based Method as a Diagnostic Biomarker for Non-Small-Cell Lung Cancer. J Thorac ()ncol,2015,10(8) -1163-1171.
ILIEM, HOFMAN V, LONG-MIRA E, et al. “Sentinel” circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease. PLoS One, 2014, 9 (10): el 11597 [2017-01-10]. http;//journals, plos. org/plosone/article? id = 10. 1371/journal, pone. 0111597.
CHEN X.WANG X, HE H.et al. Combination of circulating tumor cells with serum carcinoembryonic antigen enhances clinical prediction of non-small cell lung cancer. PLoS One, 2015, 10(5): e0126276[2017-l-10]. http;//journals, plos. org/plosone/article? id= 10. 1371/journal, pone. 0126276.
CHEN YY, XU GB. Effect of circulating tumor cells combined withnegative enrichment and CD 15-FISH identification in diagnosis, therapy monitoring and prognosis of primary lung cancer. Med Oncol,2014,31( 12) :240.
BETTEGOWDA C, SAUSEN M. LEARY RJ, et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med,2014,6(224) :224ra24.
CHENG F, SU L, QIAN C. Circulating tumor DNA: a promising biomarker in the liquid biopsy of cancer. Oncotarget, 2016.7(30): 48832-48841.
HULBERT A, JUSUE-TORRES I. STARK A, et al. Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum. Clin Cancer Res, 2017.23(8):1998-2005.
CHEN X, BA Y, MA L, et al. Characterization of micmRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res, 2008, 18 (10):997-1006.
ROTH C, KASIM1R-BAUER S, PANTEL K. et al. Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer. Mol Oncol,2011,5(3) ;281-291.
CAZZOLI R, BUTTITTA F, DI NICOLA M, et al. MicroRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer. J Thorac Oncol,2013,8(9); 1156-1162.
RABINOWITS G, GERQEL-TAYLOR C, DAY JM, et al. Exosomal microRNA; a diagnostic marker for lung cancer. Clin Lung Cancer,2009,10( 1):42-46.
SUN J, GARFELD DH, LAM B, et al. The value of autofluorescence bronchoscopy combined with white light bronchoscopy compared with white light alone in the diagnosis of intraepithelial neoplasia and invasive lung cancer* a meta-analysis. J Thorac Oncol,2011,6(8): 1336-1344.
PIEHLER JM, TAYLOR WF. Roentgenographically occult lung cancer: pathologic fndings and frequency of multicentricity during a 10-year period. Mayo Clin Proc, 1984-59(7):453-466.
TREMBLAY A, TAGHIZADEH N, MCWILLIAMS AM, et al. Low prevalence of high-grade lesions detected with autofluorescence bronchoscopy in the setting of lung cancer screening in the pan-canadian lung cancer screening study. Chest, 2016,150(5): 1015-1022.
SHI BUY A K, NAKAJIMA T, FUJIWARA T, et al. Narrow band imaging with high-resolution bronchovideoscopy: a new approach for visualizing angiogenesis in squamous cell carcinoma of the lung. Lung Cancer,2010,69(2); 194-202.
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