Difference of Liver Enzymes in Different Metabolism States of Chronic Hepatitis B
Abstract
To analyze the difference of liver enzymes in different metabolism state groups of chronic hepatitis B (CHB). Methods We use prospective cross-sectional study to analyze the difference of liver enzymes in different metabolism state groups in 110 cases of CHB, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and glutamyl transferase (GGT). Results Regardless of the presence or absence of fatty liver, the levels of ALP and GGT were increased along with the deterioration of glucose metabolism (P<0.05).The levels of ALP and GGT in the presence of fatty liver group were higher than those in the absence of fatty liver group (P<0.05). The levels of AST, ALP and GGT showed the trend of increasing along with the increase of HOMA-IR and the decrease of HOMA-β. There was no difference of liver enzymes among the groups with or without other metabolism disorder (P>0.05). Conclusions In CHB, abnormal glucose metabolism and fatty liver can lead to the increase of ALP and GGT. The increase of HOMA-IR and the decrease of HOMA-β may lead to the increase of AST,ALP and GGT. Other metabolism disorder did not show any effect on the level of liver enzymes.
Keywords: Chronic hepatitis B, Metabolism state, Liver enzyme, Difference Analysis
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HONG NS, KIM JO, LEE YM. Et al. Different associations between obesity and impaired fasting glucose depending on serum gamma-glutamyltransferase levels within normal range: a cross-sectional study. BMC Endocr Disord,2014 ,14 (1): 1-8.
KIM HY.CHO HK, YOO SK, et al. Hepatic STAMP2 deceases hepatitis В virus X protein-associated metabolic deregulation. Exp Mol Med.2012,44(10); 622-632.
KIM KH. SHIN HJ, KIM K, et al. Hepatitis В virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma. Gastroenterolory, 2007, 132 (5);1955-1967.
LAI H. JIN Q, LIN Y, et al. Combined use of lysyl oxidase, carcino-embryonic antigen, and carbohydrate antigens improves the sensitivity of biomarkers in predicting lymph node metastasis and peritoneal metastasis in gastric cancer. Tumour Biol,2014 ,35( 10) : 10547-10554.
GAO X, ZHANG S, ZHU Z. Lysyl oxidase rsl800449 polymorphism and cancer risk among Asians: evidence from a meta-analysis and a case-control study of colorectal cancer. Mol Genet Genomics,2015 »290( 1) :23-28.
PERRYMAN L. ERLER JT. Lysyl oxidase in cancer research. Future Oncol,2014 ,10(9): 1709-1717. PAPADANTONAKIS N, MATSUURA S, RAVID K. Megakaryocyte pathology and bone marrow fibrosis; the lysyl oxidase connection. Blood.2012,120(9); 1774-1781.
JI F, WANG Y, QIU L, et al. Hypoxia inducible factor la- mediated LOX expression correlates with migration and invasion in epithelial ovarian cancer. Int J Oncol, 2013, 42 (5):1578-1588.
AGRA N, CIDRE F, GARCIA-GARCIA L, et al. Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in Ewing sarcoma cells. PLoS One, 2013, 8 ( 6): e66281 [2016- 10-07]. http;//doi. org/10. 1371/journal, pone. 0066281.
WANG Y, MA J, SHEN H, et al. Reactive oxygen species promote ovarian cancer progression via the HIF-la/LOX/E- cadherin pathway. Oncol Rep,2014 ,32(5);2150-2158.
LIU JL, WEI W. TANG W. et al. Silencing of lysyl oxidase gene expression by RNA interference suppresses metastasis of breast cancer. Asian Рас J Cancer Prev,2012,13(7);3507- 3511.
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