Correlation of Thyroid Autoantibodies, System Lupus Erythematosus Immunologic Indicators and Disease Activity in SLE with HT
Abstract
To investigate the correlation of disease activity and thyroid indicators , immunologic markers of system lupus erythematosus (SLE) in SLE with Hashimoto’s thyroiditis (HT). MethodsThe clinical data of 63 cases of SLE with HT were collected. According to Systemic lupus erythematosus disease activity index 2000 (SLEDAI-2000), we classified the patients into four groups, which were remission group (5 cases), low (19 cases), moderate (12 cases) and high (27 cases) disease activity group. Each patient received the measurement of thyroid function indicators and autoantibodies, SLE immunologic indicators, serum complement (C3, C4), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and routine blood test. The correlation of thyroid indicators, immunologic markers and disease activity were analyzed. ResultsThe difference of free triiodothyronine (FT3) level in the four groups was statistically significant (P<0.05), and FT3 was negatively correlated with SLE disease activity （P=0.007）. There was no significant difference in other thyroid indicators and autoantibodies between the different groups (P>0.05). Negative correlation was found between FT3 level and anti-double-stranded DNA (dsDNA), level of anti-La antibody (SSB) and thyroid stimulating hormone (TSH) or thyroid peroxidase antibody (TPOAb). Thyroglobulin autoantibody (TgAb) was negatively related with C4, and positive correlation between FT3 and C3, FT4 and C4, TgAb and IgA. ConclusionThe pathogenesis of HT is associated with the disease activity in the patients of SLE with HT.
Keywords: System lupus erythematosus, Hashimoto’s thyroiditis, Disease activity, Autoantibody
Full Text:
PDFReferences
ADRIANA RV, TORO CE, GERARD E. et al. Factors influencing polyautoimmunity in systemic lupus erythematosus. Autoimmun Rev,2010,9(4);229-232.
CATUREGLI P. REMIGIS AD, ROSE N, et al. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev, 2014,13(4/5);391-397.
PETRI M, ORBAI AM, ALARCON GS,et al. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum.2012,64(8);2677-2686.
GLADMAN DD, IBANEZ D, UROWITZ MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol,2002,29(2):288-291.
POSSEI-T RT, COELHO VN, SKARE TL. Hashimoto thyroiditis, anti-thyroid antibodies and systemic lupus erythematosus. Int J Rheum Dis, 2017[2017-09-Ю]. http:// onlinelibrary. wiley. com/doi/10. 1111/1756-185X. 13089/ abstract; jsessionid = 7A82A6AC 43D725DE05AF59D9F744 024F. f04t04.
PAN XF, GU JQ, SHAN ZY. Patients with systemic lupus erythematosus have higher prevalence of thyroid autoantibodies:a systematic review and meta-analysis. PLoS One,2015, 10(4 ): e0123291 [2017-09-10]. http;//journals. plos.org/plosone/ article/file? id =10. 1371/journal, pone. 0123291 &-type = printable. doi; 10. 1371/journal, pone. 0123291
MACOMB PA, CHALK JB. PENDER MP. Familial occurrence of multiple sclerosis with thyroid disease and systemic lupus erythematosus. J Neurol Sci, 1990,97( 2/3): 163-171.
DAGENAIS P, UROWITZ MB, GLADMAN DD, et al. A family study of the antiphospholipid syndrome associated with other autoimmune diseases. J Rheumatol. 1992,19(9): 1393- 1396.
ROBAZZI TC. ADAN LF. Autoimmune thyroid disease in patients with rheumatic diseases. Rev Bras Reumatol,2012, 52(3);417-430.
FRANCO JS, AMAYA-AMAYA J, MOLANO-GONZdLEZ N, et al. Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus. Clin Endocrinol (Oxf) , 2015,83(6):943-950.
LIN JD, WANG YH, LIU CH. et al. Association of IRF8 gene polymorphisms with autoimmune thyroid disease. Eur J Clin Invest,2015,45(7) ;711-719.
PULLMANN RJ, LUKAC J, SKERENOVd M. et al. Cytotoxic T lymphocyte antigen 4 (CTLA-4) dimorphism in patients with systemic lupus erythematosus. Clin Exp Rheumatol, 1999,17(6): 725-729.
HAMZA RT, AWWADKS, TEMSAH KA, et al. R620W polymorphism of protein tyrosine phosphatase PTPN22 in Egyptian children and adolescents with systemic lupus erythematosus: relation to thyroid autoimmunity. Int J Adolesc Med Health,2013,25(2): 143-149.
NAMJOU B. KELLY JA, KILPATRICK J, et al. Linkage at 5ql4. 3-15 in multiplex systemic lupus erythematosus pedigrees stratified by autoimmune thyroid disease. Arthritis Rheum,2005,52( 11):3646-3650.
YE S, CHEN XX, LU XY, et al. Adult clinically amyopathic dermatomyositis with rapid progressive interstitial lung disease;a retrospective cohort study. Clin Rheumatol, 2007, 26(10):1647-1654.
SATO S, HIRAKATA M. KUWANA M , et al. Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis. Arthritis Rheum,2005,52(5): 1571-1576.
KOBAYASHI N, TAKEZAKI S, KOBAYASHI I, et al. Clinical and laboratory features of fatal rapidly progressive interstitial lung disease associated with juvenile dermatomyositis. Rheumatology (Oxford) ,2015,54(5): 784- 791.
KIVANC T, KULAKSIZOGLU S, LAKADAMYALI H, et al. Importance of laboratory parameters in patients with obstructive sleep apnea and their relationship with cardiovascular diseases. J Clin Lab Anal,2017[2017-07-21]. https://doi. org/10. 1002/jcla. 22199
OZTURK ZA, KUYUMCU ME. YESIL Y, etui. Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients? J Endocrinol Invest,2013,36(8):593-599.
ARTAQM, UYSAL M, KARA A gAQ M, et al. Prognostic Impact of Neutrophil/Lymphocyte Ratio, Platelet Count, CRP. and Albumin Levels in Metastatic Colorectal Cancer Patients Treated with FOLFIRI-Bevacizumab. J Gastrointest Cancer,2017,48(2); 176-180.
YANG W, WANG X, ZHANG W, et al. Neutrophil- lymphocyte ratio and platelet-lymphocyte ratio are 2 new inflammatory markers associated with pulmonary involvement and disease activity in patients with dermatomyositis. Clin Chim Acta, 2017, 465: 11-16[2017-10-23]. http;//doi: 10. 101G/j. cca. 201G. 12. 007.
Refbacks
- There are currently no refbacks.
