Review of Research Progress in Biliary Substitutes

YANG Li-ping, LIN Yi-xin, FENG Li, JIANG Xia

Abstract

Research and development of artificial biliary substitutes is an indispensable part of modern biliary surgery, bearing great clinical significance on the recovery of the normal functions of the biliary system. The implantation of artificial biliary substitutes may cause the blockage or stenosis of the biliary duct at the transplantation site, which is the most urgent problem in the research of artificial biliary substitutes. The fundamental cause of the problem is tissue hyperplasia caused by chronic inflammatory stimulation of artificial biliary substitutes. The regeneration of new bile duct tissue at the transplantation site can provide a solution to this problem. By looking at the literature from China and abroad, this paper reviewed the research and development of non-degradable artificial bile duct, degradable artificial bile duct and tissue-engineered artificial bile duct in order to provide reference for the further development of biliary replacements. Future studies should focus on the rapid formation of biliary epithelial layer on the tissue-engineered artificial biliary wall, the promotion of new biliary tissue formation, and the regulation of the degradation performance and mechanical properties of artificial biliary duct in order to fundamentally solve the problems encountered in the research of artificial biliary substitutes and accelerate the development of artificial biliary duct.

 

Keywords: Biliary substitutes, Repair and regeneration, Artificial bile duct

 

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References


BIJL E J， BHARWANI K D， HOUWEN R H J， et al. The long-term outcome of the Kasai operation in patients with biliary atresia: A systematic review. Neth J Med， 2013， 71(4):170–173.

HOPKINS P C， YAZIGI N， NYLUND C M. Incidence of biliary atresia and timing of hepatoportoenterostomy in the United States. J Pediatr， 2017， 187: 253-257[2021-01-17]. https://doi.org/10.1016/j.jpeds.2017. 05.006.

PEARSE H E. Vitallium tubes in biliary surgery. Ann Surg，1942，115(6): 1031–1042.

GULATI S M， IYENGAR B， THUSOO T K， et al. Use of dacron velour in choledochoplasty—An experimental-study. Am Surgeon，1983，49(8): 440–445.

HUGHES J F， LONTZ J F. Correction of biliary obstruction using a novel polytetrafluoroethylene artificial bile duct. Del Med J，1964，36(7): 150–159.

HARTUNG H， KIRCHNER R， BABA N， et al. Histological, laboratory, and X-ray findings after repair of the common bile duct with a Teflon graft. World J Surg，1978，2(5): 639–642.

MENDELOWITZ D S， BEAL J M. Expanded polytetrafluoroethylene in reconstruction of the canine biliary system. Am J Surg，1982，143(2): 221–224.

RUKA M， ROWINSKI W A， LIPSKI M， et al. Expanded polytetrafluoroethylene grafts in restoring bile drainage in dogs. Z Exp Chir Transplant Kunstliche Organe，1987，20(6): 317–323.

GOMEZ N A， ALVAREZ L R， MITE A， et al. Repair of bile duct injuries with Gore-Tex vascular grafts: experimental study in dogs. J Gastrointest Surg，2002，6(1): 116–120.

GINSBERG G， COPE C， SHAH J， et al. In vivo evaluation of a new bioabsorbable self-expanding biliary stent. Gastrointest Endosc，2003， 58(5): 777–784.

MIYAZAWA M， TORII T， TOSHIMITSU Y， et al. A tissue-engineered artificial bile duct grown to resemble the native bile duct. Am J Transplant，2005，5(6): 1541–1547.

AIKAWA M， MIYAZAWA M， OKADA K， et al. Regeneration of extrahepatic bile duct—Possibility to clinical application by recognition of the regenerative process. J Smooth Muscle Res，2007，43(6): 211–218.

AIKAWA M， MIYAZAWA M， OKADA K， et al. M1894 Development of an artificial bile duct made of bioabsorbable polymer to be used for treatment of biliary stenosis. Gastroenterology，2008，134(4): A-805. TASHIRO H， OGAWA T， ITAMOTO T， et al. Synthetic bioabsorbable stent material for duct-to-duct biliary reconstruction. J Surg Res，2009， 151(1): 85–88.

PARK S H， KANG B K， LEE J E， et al. Design and fabrication of a thin-walled free-form scaffold on the basis of medical image data and a 3D printed template: Its potential use in bile duct regeneration. ACS Appl Mater Interfaces，2017，9(14): 12290–12298.

LI H H， YIN Y X， XIANG Y， et al. A novel 3D printing PCL/GelMA scaffold containing USPIO for MRI-guided bile duct repair. Biomed Mater，2020，15(4): 045004[2021-01-17]. https://doi.org/10.1088/1748-605X/ab797a.

ROSEN M. Small intestinal submucosa as a bioscaffold for biliary tract regeneration. Surgery，2002，132(3): 480–486.

GOMEZ N A， ZAPATIER J A， VARGAS P E. Re: "Small intestinal submucosa as a bioscaffold for biliary tract regeneration". Surgery，2004， 135(4): 460.


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