Effect of Dermal Multipotent Cells Transplantation on Skin Elasticity in Aged Murine

XUE Si-liang, LI Li, HUANG Shan-shan. et al

Abstract

To investigate the elasticity changes in aged dermis after injection of dermal multipotent cells (DMCs). Methods Dermal multipotent cells were isolated and cultured from 3-day-old BALB/c mice and then transplanted into the dermis of aged (12-week-old) BALB/c mice. Adult fibroblasts（FBs） were employed as control. At 2 and 4 weeks after the transplantation, we examined dermal elasticity by MPA580 skin test machine. Results The skin elasticity were improve at 2 weeks after the transplantion in both DMCs group and FBs group ( P= 0.000) but have no statistical difference between these two groups ( P=0.216). The different effect between these two groups appeared in 4 weeks after the transplantation ( P=0.031）. Conclusion Dermal multipotent cells appear more effective than fibroblasts in increasing skin elasticity.

 

Keywords: Dermal, Multipotency, Differntiation 

 


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References


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