Characteristics and Clinical Significance of Outer Retinal Tubulation in Wet Age-macular Degeneration Treated by Anti- vascular Endothelial Growth Factor Through Optical Coherence Tomography
Abstract
To determine the characteristics and clinical significance of outer retinal tabulation (ORT) in wet age-related macular degeneration (wAMD) treated by anti-vascular endothelial growth factor （anti-VEGF） through optical coherence tomography (OCT). Methods The 35 wAMD patients with 39 ORT eyes treated by anti-VEGF were examined by OCT to determine the morphological features and evolution of the ORTs over time and their response to anti-VEGF. Results ORTs were located in the places that exudation or edema had happened in the outer nuclear layer of retina. 38 ORTs remained stable on both quantity and morphology. One ORT became invisible temporarily and then reappeared. Conclusion ORTs are reconstructed by photoreceptor cells that have survived after outer retina damages. There is no connection between anti-VEGF treatment and ORT formation.
Keywords: Outer retinal tubulation (ORT), Optical coherence tomography(OCT), Age-related macular degeneration (AMD), Anti-vascular endothelial growth factor (anti-VEGF)
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ZWEIFEL SA, ENGELBERT M, LAUD К .etui. Outer retinal tubulation; a novel optical coherence tomography finding. Arch Ophthalmol,2009»127( 12): 1596-1602. DOLZ-MARCO R. GALLEGO-PINAZO R. PINAZODUR
NM, el ul. Outer retinal tubulation analysis in cases of macular dystrophy. Archivos de la Sociedad Espanola de Oftalmologia (English Ed) ,2013,4(88) ; 161-162. FARIA-CORREIA F. BARROS-PEREIRA R, QUEIROS- MENDANHA L, et ul. Characterization of neovascular age- related macular degeneration patients with outer retinal tubulations. ()phthalmologica,2013,229(3): 147-151. GOLDBERG NR. GREENBERG JP, LAUD K, etui. Outer retinal tubulation in degenerative retinal disorders. Retina (Philadelphia, Pa),2013,33(9):1871.
HARIRI A, NITTALA MG, SADDA SR. Outer retinal tubulation as a predictor of the enlargement amount of geographic atrophy in age-related macular degeneration. Ophthalmology,2015,122(2) ;407-413.
IRIYAMA A, AIHARA Y, YANAGI Y. Outer retinal tubulation in inherited retinal degenerative disease. Retina, 2013,33(7):1462-1465.
JUNGJJ, FREUND KB. Long-term follow-up of outer retinal tubulation documented by eye-tracked and en face spectral-domain optical coherence tomography. Arch Ophthalmol,2012,130( 12); 1618-1619.
LEE JY, FOLGAR FA, MAGUIRE MG, el at. Outer retinal tubulation in the comparison of age-related macular degeneration treatments trials (CATT). Ophthalmology, 2014,121(12):2423-2431.
PAPASTEFANOU VP, NOGUEIRA V. HAY G, et al. Choroidal naevi complicated by choroidal neovascular membrane and outer retinal tubulation. Brit J Ophthalmol. 2013,97(8): 1014-1019.
WOLFF В, MATET A, VASSEUR V, et al. En face OCT imaging for the diagnosis of outer retinal tubulations in age- related macular degeneration. J Ophthalmol, 2012 ( 2012 ); 542417 [2014-12-21]. http://dx. doi. org/10. 1155/2012/ 542417.
WOLFF В, MAFTOUHI MQ. MATEO-MONTOYA A, el al. Outer retinal cysts in age-related macular degeneration. Acta ophthalmologica,2011, 89 ( 6 ); e496-e499 2015-02-01 ]. http;//onlinelibrary. wiley. com/doi/10. 1111/j. 1755-3768. 2011.02144. x/epdf.
HUA R, LIU L, HU Y, el al. The occurrence and progression of outer retinal tubulation in Chinese patients after intravitreal injections of ranibizumab. Sci Rep,2014(5) ; 7661-7661 [2015-02-01 ]. http://www. nature, com/articles/ srep07661. doijlO. 1038/srep07661.
QUERQUES C, COSCAS F, FORTE R, el al. Cystoid macular degeneration in exudative age-related macular degeneration. Am J Ophthalmol. 2011, 152( 1 ); 100-107. e2 [2015-02-01]. http;//dx. doi. org/10. 1016/j. ajo. 2011. 01. 027.
WALLACE KL, JOHNSON V, SOPELAK V, et al. Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome. Fertil Steril,2011,96(4); 1051-1056.
BARUAH J, ROY KK, RAHMAN SM. et at. Endometrial effects of letrozole and clomiphene citrate in women with polycystic ovary syndrome using spiral artery Doppler. Arch Gynecol Obstet,2009,279(3): 311-314.
ABU HASH1M H. SHOKEIR T. BADAWY A. Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome; a randomized controlled trial. Fertil Steril , 2009,94(4): 1405-1409.
XI W. LIU S, MAO H. et al. Use of letrozole and clomiphene citrate combined with gonadotropins in clomiphene-resistant infertile women with polycystic ovary syndrome; a prospective study. Drug Des Devel Ther,2015 (9); 6001-6008[2016-09-03]. https;//www. ncbi. nlm. nih. gov/pmc/articles/PMC4651359/. doi; 10. 2147/DDDT. S83259.
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycys-tic ovarysyndrome. Fertil Steril,2004,81 (1) ; 19-25.
JONARD S, DEWAILLY D. The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism. maybe the main culprit for the follicular arrest. Hum Reprod Update* 2004,10(2): 107-117.
JIRGE PR. PATIL RS. Comparison of endocrine and ultrasound profiles during ovulation induction with clomiphene citrate and letrozole in ovulatory volunteer women. Fertil Steril,2010,93( 1); 174-83.
LUPY. CHEN AL. ATKINSON EJ, et al. Minimal stimulation achieves pregnancy rates comparable to human menopausal gonadotropins in the treatment of infertility. Fertil Steril, 1996,65(3) ;583-587.
HAJISHAFIHA M. DEHGHAN M, KIARANG N, et al. Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovarysyndrome. Drug Des Devel Ther, 2013 ( 7 ): 1427-1431 [2016-09-03 ]. h11ps;//www. ncbi. nlm. nih. gov/pmc/ articles/PMC3857067/. doi: 10. 2147/DDDT. S50972.
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