Analysis on Clinical Characteristic and Risk Factors of Patients Coexistence of Cerebral Artery Stenosis with Unruptured Intracranial Aneurysm
Abstract
To analyze the incidence of intracranial unruptured aneurysms in patients with intracranial artery stenosis, clinical features, and investigate the risk factors for unruptured intracranial aneurysms. Methods Medical records from all patients performed with digital subtraction angiography (DSA) who had been treated at Peking University Third Hospital, China, from January 2012 to December 2015 were retrospectively reviewed to identify cases coexistence with cerebral artery stenosis and unruptured intracranial aneurysm. Results Of 273 patients with cerebral artery stenosis (≥50%), intracranial unruptured aneurysms was observed in 17 cases (6.23%) from age of 45 to 78, among them 8 (47.06%) were female and 9 (52.94%) were male. The incidence of unruptured intracranial aneurysm in male patients was 4.17% (9/216), and that of female was 14.4% (8/57). There was statistically significant difference between the male and female incidence of intracranial aneurysm ( P<0.05). Of these 17 patients, 16 (94.12%) aneurysms were located in the internal carotid artery (ICA) system, 1 (5.88%) aneurysm was located at the tip of the basilar artery. In 11 cases (64.71%), aneurysms were located at the distal of the stenotic vessels, 2 (11.76%) were located at the proximal of the stenotic vessels, and 4 cases (23.53%) of which the aneurysm and stenosis were not in the same artery. Logistic multivariate analysis showed that gender was an independent risk factor for aneurysms in patients with cerebral arterial stenosis. Conclusion In the intracranial artery stenosis atients, the possibility of the occurrence of the aneurysm is much higher than the general population, and women were more prominent than man. Sex is an independent risk factor for aneurysms in patients with cerebral arterial stenosis.
Keywords: Unruptured Intracranial aneurysm, Cerebral artery stenosis, Internal carotid stenosis
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HOR1KOSHI T, AKIYAMA I, YANMGAWA Z, et al. Retrospective analysis of the prescience of asymptomatic cerebral aneurysm in 4518 patients undergoing magnetic resonance angiography when does cerebral aneurysm develop? Neurol Med Chir(Tokyo) .2002.42(3): 105-113.
KANN BR, MATSUMOTO T, KERSTEIN MD. Safety of carotid endarterectomy associated with small intracranial aneurysms. South Med J, 1997. 90( 12) : 1213-1216.
INAGAWA Т, HIRANO A. Autopsy study of unruptured incidental intracranial aneurysms. Surg Neurol, 1990, 34 (6):361-365.
KAPPELLE LJ, EI-IASZIW M, FOX AJ, et al. Small, unruptured intracranial aneurysms and management of symptomatic carotid artery stenosis. North Am Symptomatic Carotid Endarterectomy Trial Group. Neurology, 2000, 55 (2):307-309.
GRIFFITHS PD, WORTHY S, GHOLKAR A. Incidental intracranial vascular pathology in patients investigated for carotid stenosis. Neuroradiology, 1996,38(1):25-30.
PAPPADAG, FIORI L, MARINA R, et al. Management of symptomatic carotid stenoses with coincidental intracranial aneurysms. Acta Neurochir (Wien), 1996, 138 ( 12); 1386- 1390.
BALLOTTA E, DA GG, MANARA R. et al. Extracranial severe carotid stenosis and incidental intracranial aneurysms. Ann Vase Surg, 2006, 20(1):5-8.
KIM JH, SUH SH, CHUNG J, et al. Prevalence and Characteristics of Unruptured Cerebral Aneurysms in Ischemic Stroke Patients. Stroke, 2016, 18(3):321-327.
HEMAN LM, JONGEN LM, VAN DER WORP HB, et al. Incidental intracranial aneurysms in patients with internal carotid artery stenosis; a CT angiography study and a metaanalysis. Stroke, 2009, 40(4) : 1341-1346.
KIM T, LEE H, AHN S,et al. Incidence and risk factors of intracranial aneurysm; a national cohort study in Korea. Int J Stroke, 2016, 11(8);917-927.
IGUCHI Y. KIMURA K, SONE K. et al. Stroke incidence and usage rate of thrombolysis in a Japanese urban city: the Kurashiki stroke registry. J Stroke Cerebrovasc Dis, 2013,22 (4):349-357.
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