Research Updates: The Role of Interaction between Oral Microbiota, Immune Cells, and Epithelial Barrier in Oral Mucosal Homeostasis and Pathogenesis

LIN Dong-jia, YANG Li-sa, WANG Zhi

Abstract

In a healthy state, the interaction between the oral microorganisms, mucosal immune cells and epithelial barrier can maintain the oral microecological stability. However, the oral microecology is disrupted under a diseased state and various pathogenic bacteria and their virulence factors and metabolites irritate the immune system, which causes direct or indirect damage to the epithelial barrier, promotes the pathogenesis and progression of oral mucosal diseases, and triggers immune inflammatory response or the irreversible transformation from inflammation into cancer. We herein reviewed the interaction between oral microorganisms, immune cells and epithelial barrier from two perspectives, the maintenance of the oral homeostasis and the pathogenesis of oral mucosal diseases. We intended to gain further understanding of the oral mucosal homeostasis and the mechanism of action of the pathogenesis and progression of oral mucosal diseases, and to provide thereby ideas and scientific and theoretical basis for developing new strategies for the diagnosis and treatment of oral mucosal diseases through re-establishing mucosal homeostasis.

 

Keywords: Oral homeostasis, Oral mucosal disease, Oral microbiota, Mucosal immunity, Epithelial barrier

 

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References


GOMEZ A， NELSON K E. The oral microbiome of children: Development, disease, and implications beyond oral health. Microb Ecol， 2017，73(2): 492–503.

AAGAARD K， MA J， ANTONY K M， et al. The placenta harbors a unique microbiome. Sci Transl Med， 2014， 6(237): 237ra65[2021-12-07]. https://doi.org/10.1126/scitranslmed.3008599.

LI H， WANG J， WU L， et al. The impacts of delivery mode on infant's oral microflora. Sci Rep， 2018， 8(1): 11938[2021-12-07]. https://doi.org/ 10.1038/s41598-018-30397-7.

CHU D M， MA J， PRINCE A L， et al. Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery. Nat Med，2017，23(3): 314–326.

CARLSSON J， GRAHNEN H， JONSSON G， et al. Early establishment of Streptococcus salivarius in the mouth of infants. J Dent Res，1970，49(2): 415–418.

WARD T L， HOSID S， IOSHIKHES I， et al. Human milk metagenome: a functional capacity analysis. BMC Microbiol， 2013， 13(1): 116[2021-12-07]. https://doi.org/10.1186/1471-2180-13-116.

VERMA D， GARG P K， DUBEY A K. Insights into the human oral microbiome. Arch Microbiol，2018，200(4): 525–540.

WAMBRE E， JEONG D. Oral tolerance development and maintenance. Immunol Allergy Clin North Am，2018，38(1): 27–37.

WAWRZYNIAK M， O'MAHONY L， AKDIS M. Role of regulatory cells in oral tolerance. Allergy Asthma Immunol Res，2017，9(2): 107–115.

CHINTHRAJAH R S， HERNANDEZ J D， BOYD S D， et al. Molecular and cellular mechanisms of food allergy and food tolerance. J Allergy Clin Immunol，2016，137(4): 984–997.

HADIS U， WAHL B， SCHULZ O， et al. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity，2011，34(2): 237–246.

HOVAV A H， WILHARM A， BAREL O， et al. Development and function of γδ T cells in the oral mucosa. J Dent Res，2020，99(5): 498–505.

BOULOUIS C， SIA W R， GULAM M Y， et al. Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli. PLoS Biol， 2020， 18(6): e3000644[2021-12-07]. https:/ /doi.org/10.1371/journal.pbio.3000644.

SCHAUPP L， MUTH S， ROGELL L， et al. Microbiota-induced type Ⅰ interferons instruct a poised basal state of dendritic cells. Cell，2020， 181(5): 1080–1096.

GROEGER S， MEYLE J. Oral mucosal epithelial cells. Front Immunol， 2019， 10: 208[2021-12-07]. https://doi.org/10.3389/fimmu.2019.00208.

BELIBASAKIS G N， KAST J I， THURNHEER T， et al. The expression of gingival epithelial junctions in response to subgingival biofilms. Virulence，2015，6(7): 704–709.

GUO W， WANG P， LIU Z H， et al. Analysis of differential expression of tight junction proteins in cultured oral epithelial cells altered by Porphyromonas gingivalis， Porphyromonas gingivalis lipopolysaccharide， and extracellular adenosine triphosphate. Int J Oral Sci. 2018， 10(1): e8[2021-12-07].https://doi.org/10.1038/ijos.2017.51.

TADA H， NISHIOKA T， TAKASE A， et al. Porphyromonas gingivalis induces the production of interleukin-31 by human mast cells， resulting in dysfunction of the gingival epithelial barrier. Cell Microbiol. 2019， 21(3): e12972[2021-12-07].https://doi.org/10.1111/cmi.12972.

ABDULKAREEM A A， SHELTON R M， LANDINI G， et al. Potential role of periodontal pathogens in compromising epithelial barrier function by inducing epithelial-mesenchymal transition. J Periodontal Res，2018， 53(4): 565–574.

LIN D J， YANG L S， WEN L L， et al. Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis. Mucosal Immunol，2021，14(6): 1247–1258.

HU L J， HE C， ZHAO C， et al. Characterization of oral candidiasis and the Candida species profile in patients with oral mucosal diseases. Microbial Pathogenesis， 2019， 134(1): 103575[2021-12-07]. https://doi. org/10.1016/j.micpath.2019.103575.

YU F Y， WANG Q Q， LI M， et al. Dysbiosis of saliva microbiome in patients with oral lichen planus. BMC Microbiol， 2020， 20(1): 75[2021-12-07]. https://doi.org/10.1186/s12866-020-01733-7.

BAEK K， CHOI Y. The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus? Mol Oral Microbiol，2018，33(1): 22–28.

CHOI Y S， KIM Y， YOON H J， et al. The presence of bacteria within tissue provides insights into the pathogenesis of oral lichen planus. Sci Rep， 2016， 6(1): 29186[2021-12-07]. https://doi.org/10.1038/srep29186.

TECCO S， SCIARA S， PANTALEO G， et al. The association between minor recurrent aphthous stomatitis (RAS)， children’s poor oral condition， and underlying negative psychosocial habits and attitudes towards oral hygiene. BMC Pediatr， 2018， 18(1): 136[2021-12-07]. https://doi.org/10.1186/s12887-018-1094-y.

RIVERA-HIDALGO F， SHULMAN J D， BEACH M M. The association of tobacco and other factors with recurrent aphthous stomatitis in an US adult population. Oral Diseases，2004，10(6): 335–345.

HIJAZI K， LOWE T， MEHARG C， et al. Mucosal microbiome in patients with recurrent aphthous stomatitis. J Dent Res，2015，94(3 Suppl): 87S–94S.

STEHLIKOVA Z， TLASKAL V， GALANOVA N， et al. Oral microbiota composition and antimicrobial antibody response in patients with recurrent aphthous stomatitis. Microorganisms， 2019， 7(12): 636[2021-12-07]. https://doi.org/10.3390/microorganisms7120636.

HU X， ZHANG Q， HUA H， et al. Changes in the salivary microbiota of oral leukoplakia and oral cancer. Oral Oncol，2016，56: e6–e8.


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